Drug stability expiration dating

Drug manufacturers are required to stamp an expiration date on their products.On over-the-counter (OTC) medicines, the expiration date is often printed on the label or carton under "EXP" or stamped without ink into the bottom of a bottle, carton, or the crimp of a tube. Is a medicine still safe to take after its expiration date?Expiration dates are typically conservative to make sure you get what you paid for—a fully potent and safe medicine.For prescription medicines there is another date to be aware of, called the “beyond use date.” This is the date that pharmacists are required to place on prescription container labels when dispensing medications.Pharmacies across the country — in major medical centers and in neighborhood strip malls — routinely toss out tons of scarce and potentially valuable prescription drugs when they hit their expiration dates.Gerona and Cantrell, a pharmacist and toxicologist, knew that the term “expiration date” was a misnomer.

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The injection remained clear and colorless in all samples throughout the study.A beyond-use date of 6 months when stored frozen at -20°C and 1 month when stored refrigerated at 4°C is appropriate for batches of the injection that have passed sterility testing.Room temperature exposure should be limited, and the vial should be returned to refrigeration as soon as possible.Chemical stability testing was performed using stability-indicating high-performance liquid chromatographic analysis.Alprostadil was the least stable of the drug components at room temperature and under refrigeration.

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